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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
49.7
Human Site:
Y728
Identified Species:
84.1
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
Y728
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
Y728
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
Y728
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
Y718
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
Rat
Rattus norvegicus
O54735
833
94538
Y686
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
Y716
L
A
T
D
L
A
L
Y
I
K
R
R
G
D
F
Chicken
Gallus gallus
P52731
862
99990
Y677
I
A
T
D
L
A
L
Y
F
K
K
R
T
M
F
Frog
Xenopus laevis
NP_001088271
859
97399
Y708
L
A
T
D
L
A
L
Y
I
K
R
R
S
D
F
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
Y714
L
A
T
D
L
A
V
Y
M
K
K
R
T
E
F
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y734
L
A
T
D
L
T
L
Y
F
E
N
R
N
S
F
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
Y975
L
S
T
D
L
A
V
Y
F
K
K
R
G
P
F
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y781
L
S
T
D
L
A
V
Y
F
K
K
K
N
K
F
Nematode Worm
Caenorhab. elegans
P91119
710
81117
K602
L
A
L
F
F
S
N
K
A
K
L
N
V
I
L
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Y733
L
S
T
D
L
A
I
Y
F
K
K
R
A
D
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
66.6
86.6
73.3
60
66.6
53.3
20
60
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
80
93.3
93.3
66.6
86.6
86.6
26.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
79
0
0
0
86
0
0
8
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
93
0
0
0
0
0
0
0
0
0
22
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
0
0
0
43
0
% E
% Phe:
0
0
0
8
8
0
0
0
36
0
0
0
0
0
93
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
50
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
50
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
93
36
8
0
8
0
% K
% Leu:
93
0
8
0
93
0
65
0
0
0
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
8
8
15
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
50
86
0
0
0
% R
% Ser:
0
22
0
0
0
8
0
0
0
0
0
0
8
8
0
% S
% Thr:
0
0
93
0
0
8
0
0
0
0
0
0
15
0
0
% T
% Val:
0
0
0
0
0
0
22
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _